beta-Aspartyl-epsilon-lysine, a peptide of the fecal contents of axenic mice.

نویسندگان

  • J P Pélissier
  • F Dubos
چکیده

Small quantities of low-molecular weight peptides have been characterized in the feces of axenic mice. In fecal material of axenic mice fed an autoclaved synthetic (SN) diet, we isolated a dipeptide and characterized its structure as beta-aspartyl-epsilon-lysine. This product was also present in the feces of gnotobiotic mice harbouring Clostridium perenne. We could not detect the product in the fecal contents of holoxenic mice, Clostridium difficile-contaminated mice or axenic mice fed the irradiated SN diet. The peptide, beta-aspartyl-epsilon-lysine, was produced by heating proteins during sterilization, causing the formation of a pseudopeptide bond between the epsilon-amino group of lysine and the amide group of asparagine. The intestinal strains seemed to differ in their ability to split this pseudopeptide bond in vivo.

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عنوان ژورنال:
  • Reproduction, nutrition, developpement

دوره 23 3  شماره 

صفحات  -

تاریخ انتشار 1983